Description

n-(4,4'-Dimethoxytrityl)-8-Bromoguanosine 2',3',5'-Triacetate is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block for the site-specific incorporation of modified guanine bases, enabling advanced research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and reliability for sensitive synthetic applications.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Drug Development: Used to create oligonucleotides with enhanced binding affinity, nuclease resistance, and specific biological activity.
• siRNA and miRNA Research: Enables the introduction of brominated guanosine for cross-linking studies, structural probing, and therapeutic agent development.
• Structural Biology Studies: Facilitates the preparation of site-specifically labeled nucleic acids for NMR and X-ray crystallography.
• Diagnostic Probe Manufacture: Employed in the production of labeled probes for genetic testing and molecular diagnostics.
• Chemical Biology Tool Development: Serves as a versatile intermediate for creating novel nucleoside analogs to study enzyme mechanisms and cellular processes.

Basic Information

Product Name	n-(4,4'-Dimethoxytrityl)-8-Bromoguanosine 2',3',5'-Triacetate
CAS No.	1096020-93-7
Molecular Formula	C35H35BrN5O10
Molecular Weight	774.59 g/mol
Synonyms	8-Bromo-2',3',5'-tri-O-acetyl-N-(4,4'-dimethoxytrityl)guanosine; 8-Br-dG(DMT) Triacetate; N-DMT-8-Bromoguanosine Triacetate; 8-Bromoguanosine, 2',3',5'-triacetate, N-(4,4'-dimethoxytrityl) derivative; Guanosine, 8-bromo-2',3',5'-triacetate, N-(bis(4-methoxyphenyl)phenylmethyl)-; Protected 8-Bromoguanosine; DMT-8-Br-Guo(OAc)3
EINECS	Contact for details

Quality Control

Every batch of n-(4,4'-Dimethoxytrityl)-8-Bromoguanosine 2',3',5'-Triacetate is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with exacting pharmaceutical and research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee reproducibility and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.