Description

Glasdegib is a potent and selective small molecule inhibitor of the Hedgehog signaling pathway, a critical target in oncology research and development. This high-purity active pharmaceutical ingredient (API) is essential for the formulation of targeted cancer therapies, particularly for the treatment of acute myeloid leukemia (AML). Glasdegib CAS NO 1095173-27-5 is primarily required by pharmaceutical manufacturers, advanced research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the production of innovative oncology drugs.

Application

• Pharmaceutical API: Primary active ingredient in the commercial formulation of targeted cancer therapeutics.
• Oncology Drug Development: Critical raw material for preclinical and clinical-stage research into Hedgehog pathway inhibitors.
• Acute Myeloid Leukemia (AML) Treatment: Key component in the manufacture of finished dosage forms indicated for specific AML patient populations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Mechanistic Studies: Used in biochemical and cellular assays to study Hedgehog pathway biology and resistance mechanisms.
• Combination Therapy Research: Investigated in conjunction with other chemotherapeutic agents for enhanced efficacy.

Basic Information

Product Name	Glasdegib
CAS No.	1095173-27-5
Molecular Formula	C21H22N6O
Molecular Weight	374.44 g/mol
Synonyms	PF-04449913; PF 04449913; PF04449913; (1R,2R,4R)-N'-(5-Chloro-2,4-dimethoxyphenyl)-N-ethyl-4-(4-morpholinyl)-2-(1H-pyrazol-5-yl)cyclopentanecarboximidamide; DAURISMO (brand name); Glasdegib Maleate (salt form); Hedgehog pathway inhibitor; SMO antagonist
EINECS	Contact for details

Quality Control

Our Glasdegib is manufactured under strict cGMP conditions to ensure the highest standards of purity and consistency required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as per ICH guidelines. We ensure compliance with relevant pharmacopeial standards and stringent internal specifications for residual solvents and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.