Description

Methyl 2-(4-Bromo-2-Nitrophenyl)-2-(Dimethoxyphosphoryl)Acetate is a high-value, multifunctional synthetic intermediate characterized by its unique combination of aryl bromide, nitro, and phosphonate ester functional groups. This compound matters for its critical role in facilitating complex carbon-carbon bond formation and serving as a versatile building block in advanced organic synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring complex aryl-substituted frameworks.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that leverage its halogenated aromatic core.
• Material Science Research: Used in the development of organic ligands, functional polymers, and advanced materials with tailored electronic properties.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) due to the reactive bromo substituent.
• Horner-Wadsworth-Emmons Olefination: The phosphonate ester moiety makes it an essential reagent for the stereoselective synthesis of alkenes and α,β-unsaturated esters.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry programs.

Basic Information

Product Name	Methyl 2-(4-Bromo-2-Nitrophenyl)-2-(Dimethoxyphosphoryl)Acetate
CAS No.	1094851-34-9
Molecular Formula	C11H13BrNO7P
Molecular Weight	382.10 g/mol
Synonyms	Dimethyl (4-Bromo-2-nitrobenzyl)phosphonoacetate; Methyl (Dimethoxyphosphoryl)(4-bromo-2-nitrophenyl)acetate; Acetic acid, 2-(4-bromo-2-nitrophenyl)-2-(dimethoxyphosphinyl)-, methyl ester; (4-Bromo-2-nitrophenyl)(dimethoxyphosphoryl)acetic acid methyl ester; Phosphonoacetic acid, (4-bromo-2-nitrophenyl)-, dimethyl ester, methyl ester; Methyl 2-(dimethoxyphosphoryl)-2-(4-bromo-2-nitrophenyl)acetate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-Bromo-2-Nitrophenyl)-2-(Dimethoxyphosphoryl)Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.