Description

1-Boc-3-(Azidomethyl)-Azetidine is a high-purity, protected azetidine derivative, serving as a critical building block in modern synthetic organic chemistry. Its value lies in the orthogonal protection of the azetidine nitrogen and the versatile azidomethyl handle, which allows for efficient downstream functionalization via click chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Peptidomimetic Chemistry: Used to incorporate constrained azetidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Bioconjugation & Probe Development: The azide group enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling biomolecules or creating chemical probes.
• Agrochemical Research: Employed in the discovery and synthesis of new herbicides and fungicides with novel modes of action.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers with specific functional properties.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening campaigns.

Basic Information

Product Name	1-Boc-3-(Azidomethyl)-Azetidine
CAS No.	1093981-23-7
Molecular Formula	C9H16N4O2
Molecular Weight	212.25 g/mol
Synonyms	tert-Butyl 3-(azidomethyl)azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(azidomethyl)azetidine; 3-(Azidomethyl)-1-Boc-azetidine; 1-Boc-3-azidomethylazetidine; N-Boc-3-(azidomethyl)azetidine; Azetidine, 3-(azidomethyl)-, 1-(1,1-dimethylethyl) ester; Boc-Azetidine(Azidomethyl)
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(Azidomethyl)-Azetidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.