Description

2-Methoxy-2'-Deoxy-2'-Fluoro-β-D-Arabinoadenosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical research and development. Its precise structure, featuring a 2'-fluoro and 2'-methoxy substitution on an arabinose sugar, is critical for modulating biological activity and stability in therapeutic oligonucleotides. This high-purity intermediate is essential for researchers and manufacturers in the fields of antisense oligonucleotide (ASO) therapeutics, siRNA development, and diagnostic probe synthesis, where it is used to enhance nuclease resistance and optimize pharmacokinetic profiles.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A vital phosphoramidite precursor for constructing therapeutic ASOs targeting genetic diseases.
• siRNA and miRNA Development: Used to introduce stabilizing modifications into small interfering RNA (siRNA) and microRNA (miRNA) strands.
• Diagnostic Probe Manufacturing: Serves as a modified base in fluorescent probes and molecular beacons for high-sensitivity detection assays.
• Medicinal Chemistry & Drug Discovery: A crucial intermediate for structure-activity relationship (SAR) studies in nucleoside-based antiviral and anticancer drug candidates.
• Academic & Biotech Research: Used in fundamental biochemical research to study nucleic acid-protein interactions and enzyme mechanisms.
• GMP-grade API Intermediate: Supplied under controlled conditions for use in the cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	2-Methoxy-2'-Deoxy-2'-Fluoro-β-D-Arabinoadenosine
CAS No.	1093278-52-4
Molecular Formula	C11H14FN5O4
Molecular Weight	299.26 g/mol
Synonyms	2'-Fluoro-2'-methoxy-β-D-arabinoadenosine; 2'-F-2'-OMe-araA; 2'-Fluoro-2'-O-methyl-arabinoadenosine; 9-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl]adenine; 2'-Deoxy-2'-fluoro-2'-methoxyadenosine; 2'-F-2'-OMe-Ado (ara); Modified Adenosine Nucleoside
EINECS	Contact for details

Quality Control

Our 2-Methoxy-2'-Deoxy-2'-Fluoro-β-D-Arabinoadenosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Production can be aligned with research-grade or cGMP standards to meet specific project requirements from discovery through clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.