Description

B-Raf Inhibitor 1 is a potent and selective small molecule inhibitor targeting the B-Raf kinase, a key protein in the MAPK/ERK signaling pathway. This compound is crucial for biochemical research and pharmaceutical development, particularly in the study of oncogenic mutations and targeted cancer therapies. It serves as an essential tool for researchers and developers in oncology, molecular biology, and medicinal chemistry, enabling the investigation of cell proliferation, differentiation, and survival mechanisms.

Application

• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies targeting B-Raf mutations, such as V600E, prevalent in melanoma, colorectal, and thyroid cancers.
• Biochemical Assay Development: Serves as a critical control compound in high-throughput screening (HTS) and enzyme inhibition assays to discover and validate new kinase inhibitors.
• Signal Transduction Studies: A key reagent for elucidating the role of the RAF-MEK-ERK pathway in cellular processes, including studies on drug resistance mechanisms.
• Medicinal Chemistry & Drug Discovery: Provides a core scaffold or intermediate for the synthesis and structure-activity relationship (SAR) optimization of novel therapeutic candidates.
• Academic & Institutional Research: Supports fundamental research in university and institutional labs focused on kinase biology and targeted therapy development.
• Pharmaceutical Development: Utilized in formulation studies, stability testing, and the development of analytical methods for potential drug products.

Basic Information

Product Name	B-Raf Inhibitor 1
CAS No.	1093100-40-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	B-Raf Inhibitor 1; B-Raf Inhibitor I; B-Raf Inhibitor; B-Raf kinase inhibitor 1; B-Raf inhibitor compound 1; (Chemical name based on structure); (IUPAC name); (Research code)
EINECS	Contact for details

Quality Control

Our B-Raf Inhibitor 1 is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere or with desiccant and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.