Description

1-(tert-Butyl-Dimethyl-Silanyl)-5-Fluoro-1H-Indole is a high-purity, advanced pharmaceutical intermediate featuring a protected indole nitrogen and a fluorine substituent. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce fluorinated indole motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorine substitution on indole-based scaffolds.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of API synthesis routes.
• Agrochemical Synthesis: Potential intermediate in the development of new fluorinated pesticides and herbicides.
• Fluorine Chemistry: A valuable reagent for introducing both fluorine and silicon-protected functional groups in complex molecule construction.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client projects.

Basic Information

Product Name	1-(tert-Butyl-Dimethyl-Silanyl)-5-Fluoro-1H-Indole
CAS No.	1093066-71-7
Molecular Formula	C₁₄H₂₀FNSi
Molecular Weight	249.40 g/mol
Synonyms	5-Fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole; 5-Fluoro-1-(tert-butyldimethylsilyl)-1H-indole; 1H-Indole, 5-fluoro-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Fluoro-1-TBDMS-indole; 5-Fluoroindole, 1-TBDMS protected; N-TBDMS-5-fluoroindole; 1-(tert-Butyldimethylsilyl)-5-fluoroindole; TBDMS-5-Fluoroindole
EINECS	Contact for details

Quality Control

Every batch of 1-(tert-Butyldimethylsilyl)-5-fluoro-1H-indole is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products meet high-purity standards suitable for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications via validated methods such as HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.