Description

5-(Trifluoromethyl)Nicotinoyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials that incorporate the versatile trifluoromethylpyridine scaffold.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic materials that require fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic and Industrial R&D: Used in research laboratories for method development and exploring new chemical entities in medicinal chemistry programs.

Basic Information

Product Name	5-(Trifluoromethyl)Nicotinoyl Chloride
CAS No.	1092506-65-4
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	5-(Trifluoromethyl)pyridine-3-carbonyl chloride; Nicotinoyl chloride, 5-(trifluoromethyl)-; 3-Pyridinecarbonyl chloride, 5-(trifluoromethyl)-; 5-Trifluoromethylnicotinoyl chloride; 5-(Trifluoromethyl)nicotinic acid chloride
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Nicotinoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.