Description

5-Fluoro-2-(Trifluoromethoxy)Benzoylchloride is a high-purity, reactive benzoyl chloride derivative serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy and fluorine substituents make it an essential precursor for introducing specific pharmacophores and enhancing the physicochemical properties of target molecules. This compound is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce fluorinated aromatic units into high-performance polymers, enhancing their thermal and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) working on client-specific fluorinated compounds.
• Research & Development: Utilized in academic and industrial R&D labs for exploring new chemical entities and reaction methodologies in fluorine chemistry.

Basic Information

Product Name	5-Fluoro-2-(Trifluoromethoxy)Benzoylchloride
CAS No.	1092460-84-8
Molecular Formula	C8H3ClF4O2
Molecular Weight	242.56 g/mol
Synonyms	5-Fluoro-2-(trifluoromethoxy)benzoyl chloride; 2-(Trifluoromethoxy)-5-fluorobenzoyl chloride; Benzoyl chloride, 5-fluoro-2-(trifluoromethoxy)-; 1092460-84-8; 5-Fluoro-α,α,α-trifluoro-o-anisoyl chloride; 5-Fluoro-2-trifluoromethoxybenzoyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Fluoro-2-(Trifluoromethoxy)Benzoylchloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We operate under a cGMP-compliant quality system suitable for pharmaceutical applications, and our facilities are prepared for regulatory audits.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Assay (Titration)	97.0 - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.