Description

8-[(R)-2-Azido-1-(tert-Butyl-Dimethyl-Silanyloxy)-Ethyl]-5-Benzyloxy-4H-Benzo[1,4]Oxazin-3-One is a sophisticated chiral building block and key synthetic intermediate of significant value in advanced organic synthesis. Its molecular architecture, featuring an azido group, a protected hydroxyl, and a benzoxazinone core, makes it a versatile precursor for constructing complex nitrogen-containing heterocycles. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, including potential CNS-active compounds.
• Agrochemical Synthesis: Used in the construction of novel herbicide and pesticide candidates with complex heterocyclic structures.
• Peptidomimetics & PROTACs: Serves as a building block for designing peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to its reactive azide functionality for "click chemistry".
• Material Science Research: Employed in the synthesis of specialized polymers and functional organic materials requiring precise molecular control.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	8-[(R)-2-Azido-1-(tert-Butyl-Dimethyl-Silanyloxy)-Ethyl]-5-Benzyloxy-4H-Benzo[1,4]Oxazin-3-One
CAS No.	1092407-76-5
Molecular Formula	C23H28N4O4Si
Molecular Weight	452.59 g/mol
Synonyms	5-Benzyloxy-8-[(1R)-2-azido-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4H-1,4-benzoxazin-3-one; (R)-8-(2-Azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-(benzyloxy)-4H-benzo[d][1,4]oxazin-3-one; 8-[(R)-2-Azido-1-(TBDMS-oxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one; TBDMS-protected azido-benzoxazinone intermediate; Azido-TBDMS-Benzoxazinone; CAS 1092407-76-5
EINECS	Contact for details

Quality Control

Our 8-[(R)-2-Azido-1-(tert-Butyl-Dimethyl-Silanyloxy)-Ethyl]-5-Benzyloxy-4H-Benzo[1,4]Oxazin-3-One is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity, critical for sensitive synthetic applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (under refrigeration) or as specified on the label or COA. For long-term storage under inert atmosphere, keep the container sealed under nitrogen or argon. The compound is light-sensitive; handle and store accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.