Description

Poziotinib (Hm781-36B) is a potent, irreversible tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) family. This compound is a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC) with specific EGFR mutations. It is essential for oncology research laboratories, pharmaceutical R&D departments, and manufacturers of active pharmaceutical ingredients (APIs) focused on precision medicine.

Application

• Oncology Research & Drug Discovery: A key biochemical tool for studying EGFR (HER2/ErbB2) signaling pathways and mechanisms of drug resistance.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of targeted therapeutic agents for clinical development.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles of novel cancer treatments.
• Mechanistic Studies: Facilitates research into the structural activity relationships (SAR) of irreversible kinase inhibitors.

Basic Information

Product Name	Poziotinib (Hm781-36B)
CAS No.	1092364-38-9
Molecular Formula	C26H25FN6O3
Molecular Weight	488.52 g/mol
Synonyms	HM781-36B; Poziotinib; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; HM 781-36B; UNII-3R6J5P4L4T; Poziotinib (HM781-36B); HM78136B
EINECS	Contact for details

Quality Control

Our Poziotinib (Hm781-36B) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.