Description

Gsk-2126458 CAS NO 1086062-66-9 is a potent and selective small-molecule inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR), key signaling nodes in the PI3K/AKT/mTOR pathway. This pathway is a critical regulator of cell growth, proliferation, and survival, making it a major target for therapeutic intervention in oncology and metabolic research. This high-purity compound is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on developing novel cancer therapies and studying cellular signaling mechanisms.

Application

• Oncology Research & Drug Discovery: A critical tool for studying the role of the PI3K/AKT/mTOR pathway in tumorigenesis and for evaluating the efficacy of pathway inhibition in various cancer cell lines and animal models.
• Biochemical & Cellular Assay Development: Used as a reference standard and active control in high-throughput screening (HTS) and functional assays to identify and characterize new PI3K/mTOR inhibitors.
• Mechanism of Action (MoA) Studies: Enables researchers to dissect complex signaling networks and understand downstream effects of dual PI3K/mTOR inhibition on apoptosis, autophagy, and cell cycle progression.
• Preclinical Pharmacology: Employed in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies to support the development of targeted cancer therapies.
• Academic Research: Facilitates fundamental research into the physiological and pathological roles of PI3K and mTOR in diseases beyond cancer, such as metabolic disorders and neurological conditions.

Basic Information

Product Name	Gsk-2126458
CAS No.	1086062-66-9
Molecular Formula	C₃₀H₂₃ClFN₇O₃S
Molecular Weight	616.06 g/mol
Synonyms	GSK2126458; GSK-2126458; Omipalisib; 2-[4-(4-Amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinyl]-5-chloro-3-[4-(methylsulfonyl)phenyl]-4(3H)-quinazolinone; PI3K/mTOR Inhibitor GSK2126458; GSK 2126458; GSK'2126458
EINECS	Contact for details

Quality Control

Our Gsk-2126458 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LC-MS for identity confirmation, and NMR for structural verification, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, batch-to-batch consistency, and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term storage, keep at 2-8°C in a dry environment. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.