Description

2-(Trifluoromethyl)-1,3-Thiazole-4-Carbonyl Chloride is a high-value, reactive chemical intermediate essential for constructing complex molecular architectures. Its core value lies in the trifluoromethyl-thiazole scaffold, which imparts desirable properties like metabolic stability and enhanced lipophilicity to target molecules. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in antiviral, antibacterial, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functionalized heterocycles used in the development of organic electronic materials and specialty polymers.
• Chemical Biology Probes: Employed in the creation of tagged molecules and activity-based probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	2-(Trifluoromethyl)-1,3-Thiazole-4-Carbonyl Chloride
CAS No.	1076197-53-9
Molecular Formula	C5H1ClF3NOS
Molecular Weight	215.58 g/mol
Synonyms	4-Thiazolecarbonyl chloride, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)thiazole-4-carbonyl chloride; 2-Trifluoromethyl-1,3-thiazole-4-carbonyl chloride; 2-Trifluoromethyl-4-thiazolecarbonyl chloride; 4-Carbonyl chloride-2-trifluoromethylthiazole; 1076197-53-9 (CAS); TFMT-COCl
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)-1,3-Thiazole-4-Carbonyl Chloride adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized using advanced analytical techniques, including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.