Description

Gepotidacin CAS NO 1075236-89-3 is a novel, first-in-class triazaacenaphthylene antibiotic that represents a significant advancement in antibacterial therapy. Its unique mechanism of action, targeting bacterial type II topoisomerases, makes it a critical tool in the global fight against antimicrobial resistance, particularly against multidrug-resistant pathogens. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing next-generation treatments for bacterial infections.

Application

• Primary Active Pharmaceutical Ingredient (API) for the formulation of novel antibacterial drugs.
• Research and development of new therapeutic agents targeting Gram-positive and Gram-negative bacteria.
• Pre-clinical and clinical studies for evaluating efficacy against drug-resistant infections like Neisseria gonorrhoeae.
• Manufacturing of finished dosage forms, such as oral tablets or intravenous solutions, for clinical use.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Investigational compound for studying novel mechanisms of bacterial topoisomerase inhibition.

Basic Information

Item	Detail
Product Name	Gepotidacin
CAS No.	1075236-89-3
Molecular Formula	C24H25FN6O3
Molecular Weight	464.49 g/mol
Synonyms	GSK2140944; GSK-2140944; GSK'0944; (1R,5S)-N1-[(7S)-7-Fluoro-3-oxo-1,2,3,4-tetrahydro-1,8-naphthyridin-6-yl]-N5-[(1S,2S,4R)-2-hydroxy-7-azabicyclo[2.2.1]heptan-7-yl]-2,7-diazaspiro[4.4]nonane-1,5-dicarboxamide; Triazaacenaphthylene antibiotic
EINECS	Contact for details

Quality Control

Our Gepotidacin is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical development and manufacturing. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC and mass spectrometry. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications aligned with ICH Q3A/B guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.