Description

Defactinib is a potent and selective small-molecule inhibitor of Focal Adhesion Kinase (FAK), a key signaling protein involved in cell adhesion, migration, proliferation, and survival. This compound matters for its significant role in preclinical oncology research, particularly in studying tumor metastasis, cancer stem cells, and overcoming drug resistance. It is primarily needed by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on developing novel anti-cancer therapeutics and understanding FAK-mediated signaling pathways.

Application

• Oncology Research: A critical tool for investigating the role of Focal Adhesion Kinase (FAK) in tumor progression, metastasis, and the tumor microenvironment.
• Drug Resistance Studies: Used to explore mechanisms of chemoresistance and evaluate FAK inhibition as a strategy to sensitize cancer cells to conventional therapies.
• Preclinical Drug Development: Serves as a reference compound or lead molecule in the discovery and optimization of novel FAK-targeted anti-cancer agents.
• Cell Signaling & Pathway Analysis: Employed in biochemical and cellular assays to dissect FAK-related signaling cascades and their cross-talk with other pathways.
• Cancer Stem Cell Research: Investigated for its potential to target and inhibit cancer stem cell populations which are often drivers of recurrence and metastasis.
• Angiogenesis Inhibition Studies: Applied in research exploring the inhibition of FAK to disrupt tumor angiogenesis and blood vessel formation.

Basic Information

Product Name	Defactinib
CAS No.	1073154-85-4
Molecular Formula	C20H21N5O2
Molecular Weight	363.42 g/mol
Synonyms	VS-6063; PF-04554878; PF-562271 (Note: PF-562271 is a closely related analog, often referenced together); 1,2,4-Triazolo[1,5-a]pyrazine, 6-[4-[[4-(ethylsulfonyl)-1-piperazinyl]methyl]phenyl]-N-(5-methyl-2-pyrazinyl)-; FAK Inhibitor 14; Focal Adhesion Kinase Inhibitor VS-6063
EINECS	Contact for details

Quality Control

Our Defactinib is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, MS), purity determination by HPLC, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. For long-term storage, consider storing desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.