Description

11-cis-Acitretin is a specific geometric isomer of the synthetic retinoid acitretin, a second-generation compound related to vitamin A. This precise stereochemistry is critical for research into retinoid receptor binding affinity and metabolic pathways, offering a defined tool for pharmacological studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical reference standard providers investigating dermatological treatments, cellular differentiation, and retinoid biology.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for quality control and analytical method development in drug manufacturing.
• Biochemical Research: Used as a precise molecular probe to study the structure-activity relationships (SAR) of retinoids and their interaction with nuclear receptors (RARs/RXRs).
• Metabolic Pathway Analysis: Investigates the in-vivo and in-vitro isomerization and metabolism of acitretin and related compounds.
• Dermatology R&D: A key intermediate or active pharmaceutical ingredient (API) impurity standard in the development of treatments for severe psoriasis and other keratinization disorders.
• Academic Studies: Employed in university and institutional research focused on cell proliferation, differentiation, and apoptosis mechanisms.

Basic Information

Product Name	11-cis-Acitretin
CAS No.	1067630-53-8
Molecular Formula	C21H26O3
Molecular Weight	326.43 g/mol
Synonyms	(2E,4E,6Z,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid; 11-Z-Acitretin; cis-Acitretin; (11Z)-Acitretin; All-trans-Acitretin Impurity; Retinoid Ro 10-1670 Isomer
EINECS	Contact for details

Quality Control

Our 11-cis-Acitretin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.