Description

Lefamulin is a novel, semi-synthetic pleuromutilin antibiotic specifically developed to combat serious community-acquired bacterial pneumonia (CABP). Its unique mechanism of action, inhibiting bacterial protein synthesis by binding to the peptidyl transferase center of the 50S ribosomal subunit, makes it a critical tool against multidrug-resistant pathogens. This product is essential for pharmaceutical R&D, reference standard preparation, and the synthesis of advanced antibacterial agents targeting Gram-positive and atypical bacteria.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of antibacterial drugs for the treatment of community-acquired bacterial pneumonia (CABP).
• Reference Standard & Analytical Testing: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and pharmacokinetic studies.
• Biomedical Research: A vital tool for in vitro and in vivo studies investigating bacterial resistance mechanisms and the efficacy of novel pleuromutilin derivatives.
• Drug Discovery & Development: Serves as a key intermediate or lead compound for synthesizing new antibiotics with improved potency and safety profiles.
• Veterinary Medicine Development: Investigated for potential applications in treating bacterial infections in animals, given the pleuromutilin class's history in veterinary use.

Basic Information

Product Name	Lefamulin
CAS No.	1061337-51-6
Molecular Formula	C₂₈H₄₅NO₅S
Molecular Weight	507.73 g/mol
Synonyms	BC-3781; (1S,2S,3S,4R,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0¹,⁸]tetradec-6-yl (2S)-2-amino-3,3-dimethylbutanethioate; NVP-BC3781; XENLETA (brand name); Pleuromutilin derivative; Antibiotic BC 3781
EINECS	Contact for details

Quality Control

Our Lefamulin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet exacting standards for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with ICH guidelines and cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.