Description

Anlotinib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor (TKI) with significant therapeutic potential. Its primary value lies in its ability to inhibit key angiogenesis and tumor proliferation pathways, making it a critical active pharmaceutical ingredient (API) for advanced oncology research and development. This compound is essential for pharmaceutical manufacturers, research institutions, and CROs (Contract Research Organizations) focused on developing next-generation cancer therapeutics, particularly for non-small cell lung cancer and other solid tumors.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of anti-cancer drugs.
• Key component in preclinical and clinical research for tyrosine kinase inhibitor efficacy and mechanism of action studies.
• Development of targeted therapies for non-small cell lung cancer (NSCLC), thyroid cancer, and soft tissue sarcoma.
• Utilized in pharmacology and toxicology studies to establish dosing and safety profiles.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Building block for medicinal chemistry research aimed at developing novel kinase inhibitor derivatives.

Basic Information

Product Name	Anlotinib
CAS No.	1058156-90-3
Molecular Formula	C23H22FN3O3
Molecular Weight	407.44 g/mol
Synonyms	Anlotinib Hydrochloride (common salt form); AL3818; 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropanamine; N-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-quinolyloxy)cyclopropyl)formamide; C23H22FN3O3
EINECS	Contact for details

Quality Control

Our Anlotinib is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP (Current Good Manufacturing Practice) guidelines where applicable to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.