Description

Momelotinib is a potent and selective small-molecule inhibitor of Janus kinase 1 (JAK1) and JAK2. This compound is of significant interest for its therapeutic potential in modulating key signaling pathways involved in cellular proliferation and immune response. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in oncology and hematology research, particularly for conditions like myelofibrosis.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of JAK inhibitor therapies.
• Oncology & Hematology Studies: Used in preclinical and clinical research targeting myeloproliferative neoplasms (MPNs), including myelofibrosis, polycythemia vera, and essential thrombocythemia.
• Biochemical Assay Development: Employed as a selective inhibitor to study JAK-STAT signaling pathways in various cell-based and enzymatic assays.
• Mechanism of Action (MoA) Research: A key tool compound for investigating the role of JAK1/JAK2 inhibition in inflammatory and autoimmune disease models.
• Process Chemistry & Scale-Up: Used as a building block or intermediate in the synthetic route for producing GMP-grade momelotinib.
• Academic Research: Facilitates basic scientific research into tyrosine kinase function and signal transduction in university and institutional laboratories.

Basic Information

Product Name	Momelotinib
CAS No.	1056634-68-4
Molecular Formula	C₂₃H₂₂N₆O₂
Molecular Weight	414.46 g/mol
Synonyms	GS-0387; CYT387; 9H-Purin-6-amine, 2-(4-morpholinyl)-9-(1-piperidinyl)-; (2E)-N-(4-{[1-(1H-indazol-3-yl)ethyl]amino}quinazolin-2-yl)-2-cyano-3-[4-(dimethylamino)phenyl]acrylamide; INCB-039110; 1-Piperidinepropanamide, α-cyano-N-[4-[[(1H-indazol-3-yl)ethyl]amino]-2-quinazolinyl]-3-(4-dimethylaminophenyl)-2-propen-
EINECS	Contact for details

Quality Control

Our Momelotinib is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to relevant guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.