Description

(E)-4-(Dimethylamino)But-2-Enoyl Chloride is a high-purity, reactive chemical intermediate featuring an α,β-unsaturated carbonyl system activated by an acid chloride group. This compound is valued for its role as a key building block in the synthesis of complex molecules, enabling efficient carbon-carbon and carbon-heteroatom bond formation. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs), ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those containing enone or β-amino carbonyl motifs found in various therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its reactive chloride group facilitates the introduction of the dimethylaminoenoyl moiety.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of novel polymers with specific optical or electronic properties.
• Chemical Biology Probes: Employed to create activity-based probes or affinity labels for studying enzyme function and protein interactions.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	(E)-4-(Dimethylamino)But-2-Enoyl Chloride
CAS No.	1055943-40-2
Molecular Formula	C6H10ClNO
Molecular Weight	147.60 g/mol
Synonyms	(E)-4-(Dimethylamino)but-2-enoyl chloride; 4-(Dimethylamino)-2-butenoyl chloride, (E)-; trans-4-(Dimethylamino)crotonoyl chloride; (2E)-4-(Dimethylamino)-2-butenoyl chloride; N,N-Dimethyl-2-butenoyl chloride; 4-Dimethylaminocrotonoyl chloride; But-2-enoyl chloride, 4-(dimethylamino)-, (E)-; DMABC
EINECS	Contact for details

Quality Control

Every batch of (E)-4-(Dimethylamino)But-2-Enoyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.