Description

n-[2-(Methylthio)Ethyl]-2-[(3,3,3-Trifluoropropyl)Thio]-Adenosine 5''-(Hydrogen p-1H-Imidazol-1-Ylphosphonate) CAS NO 1054332-15-8 is a sophisticated, high-purity nucleoside analog derivative designed for advanced research and development. This compound is critical for scientists exploring novel pathways in medicinal chemistry and biochemistry, particularly in the development of enzyme inhibitors and targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic research institutions focused on nucleotide-based drug discovery and biochemical mechanism studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis of novel nucleoside-based therapeutics, including potential antiviral or anticancer agents.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies to investigate adenosine-related pathways and receptor interactions.
• Medicinal Chemistry: Acts as a building block for the design and synthesis of modified nucleotides with tailored biological activity and improved metabolic stability.
• Process Development: Employed in scaling up synthetic routes for nucleotide analogs under current Good Manufacturing Practice (cGMP) conditions for preclinical and clinical trial material production.
• Academic Research: Utilized in university laboratories for fundamental studies on nucleotide chemistry, structure-activity relationships (SAR), and molecular modeling.
• Diagnostic Reagent Development: Potential use in the formulation of specialized assay kits or probes for detecting specific enzymatic activity or biomarkers.

Basic Information

Product Name	n-[2-(Methylthio)Ethyl]-2-[(3,3,3-Trifluoropropyl)Thio]-Adenosine 5''-(Hydrogen p-1H-Imidazol-1-Ylphosphonate)
CAS No.	1054332-15-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenosine, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, 5'-(hydrogen P-1H-imidazol-1-ylphosphonate); 2'-Deoxy-2'-[(3,3,3-trifluoropropyl)thio]-N-[2-(methylthio)ethyl]adenosine 5'-(imidazolylphosphonate); 5'-(1H-Imidazol-1-ylphosphono)-2-[(3,3,3-trifluoropropyl)thio]-N-[2-(methylthio)ethyl]adenosine; Modified S-Adenosylhomocysteine Analog; Nucleoside Phosphonate Ester; SAH Hydrolase Inhibitor Intermediate; Thioether-Modified Adenosine Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support development projects requiring material produced under cGMP guidelines for preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccants and temperature monitoring.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by HPLC)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.