Description

8-Hydroxydigitoxigenin is a hydroxylated derivative of the cardenolide digitoxigenin, serving as a key intermediate and reference standard in advanced pharmaceutical research. This compound is of significant interest for its role in the study and development of cardiac glycosides and their therapeutic mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular drug discovery, metabolic studies, and the synthesis of novel bioactive derivatives.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in drug development pipelines.
• Cardiovascular Research: A critical intermediate for investigating the structure-activity relationships (SAR) of cardiac glycosides targeting Na+/K+-ATPase.
• Metabolic Pathway Studies: Employed in in vitro and in vivo studies to understand the biotransformation and pharmacokinetics of digitoxigenin-based compounds.
• Organic Synthesis: Serves as a versatile building block for the semi-synthesis of novel cardenolide analogs with potential enhanced efficacy or reduced toxicity.
• Biochemical Assays: Utilized in enzyme inhibition assays and receptor binding studies to elucidate precise mechanisms of action.

Basic Information

Product Name	8-Hydroxydigitoxigenin
CAS No.	1049674-06-7
Molecular Formula	C₂₃H₃₄O₅
Molecular Weight	390.51 g/mol
Synonyms	8-Hydroxydigitoxigenin; Digitoxigenin, 8-hydroxy-; 3β,14-Dihydroxy-5β-card-20(22)-enolide; 8-Hydroxy-3β,14-dihydroxy-5β-card-20(22)-enolide; 8-OH-Digitoxigenin
EINECS	Contact for details

Quality Control

Every batch of 8-Hydroxydigitoxigenin is manufactured and tested under a strict quality management system to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.