Description

3′-o-Azidomethyl-N6-Bz Da CAS NO 1048021-75-5 is a specialized, chemically modified nucleoside derivative designed for advanced oligonucleotide synthesis and bioconjugation applications. This compound is engineered to introduce specific functional handles, enabling precise cross-linking and labeling in nucleic acid research and therapeutic development. It is an essential building block for researchers and manufacturers in the fields of pharmaceutical R&D, diagnostic probe development, and oligonucleotide-based therapeutics, where controlled modification is critical.

Application

• Oligonucleotide Synthesis: Key monomer for the solid-phase synthesis of modified DNA/RNA strands, introducing azide groups for subsequent "click chemistry" reactions.
• Bioconjugation & Labeling: Enables site-specific attachment of fluorophores, peptides, or other molecules to nucleic acids for diagnostic assays and imaging.
• Antisense & siRNA Therapeutics: Used in the development of stabilized and targeted oligonucleotide drugs to enhance delivery and efficacy.
• Chemical Biology Probes: Serves as a critical tool for studying nucleic acid-protein interactions and cellular processes.
• Next-Generation Sequencing (NGS): Can be utilized in the preparation of uniquely tagged sequencing libraries.
• Academic & Industrial R&D: Fundamental reagent for exploratory research in medicinal chemistry and molecular biology.

Basic Information

Product Name	3′-o-Azidomethyl-N6-Bz Da
CAS No.	1048021-75-5
Molecular Formula	C18H18N8O5
Molecular Weight	426.39 g/mol
Synonyms	3'-O-Azidomethyl-N6-Benzoyl-2'-deoxyadenosine; 3'-Azidomethyl-N6-Benzoyl-2'-deoxyadenosine; 2'-Deoxyadenosine, 3'-O-(azidomethyl)-N6-benzoyl-; N6-Benzoyl-3'-O-azidomethyl-2'-deoxyadenosine; 3'-O-(Azidomethyl)-N6-benzoyl-2'-deoxyadenosine; 3'-Azidomethyl-N6-Bz-dA; Azidomethyl-dA(Bz) phosphoramidite precursor
EINECS	Contact for details

Quality Control

Every batch of 3′-o-Azidomethyl-N6-Bz Da is produced under stringent quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your specific research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.