Description

Gsk2141795 (Hydrochloride) is a potent and selective small molecule inhibitor of the AKT (Protein Kinase B) signaling pathway. This compound is of significant value for biochemical and pharmacological research, particularly in the study of cancer cell proliferation, survival, and metabolism. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, metabolic disorders, and signal transduction pathways.

Application

• Biochemical Research: Used as a critical tool compound to selectively inhibit AKT kinase activity in in vitro enzyme assays and cell-based studies.
• Oncology Research: Investigated for its effects on tumor cell growth, apoptosis, and resistance mechanisms in various cancer models, including breast, prostate, and ovarian cancers.
• Signal Transduction Studies: Employed to elucidate the role of the PI3K/AKT/mTOR pathway in cellular processes, aiding in target validation and pathway mapping.
• Preclinical Development: Serves as a reference standard or lead compound in the discovery and optimization of novel therapeutic agents targeting AKT.
• Metabolic Disease Research: Applied in studies exploring the connection between AKT signaling and metabolic syndromes such as diabetes.
• Cell Culture & Functional Assays: Utilized to modulate AKT-dependent cellular functions in a controlled research environment to understand specific biological outcomes.

Basic Information

Product Name	Gsk2141795 (Hydrochloride)
CAS No.	1047635-80-2
Molecular Formula	C23H24N8O2 • HCl
Molecular Weight	480.95 g/mol (Free base: 444.49 g/mol)
Synonyms	Gsk2141795 HCl; GSK2141795; GSK-2141795; Uprosertib (Hydrochloride); 5-[2,6-Di-4-morpholinyl-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine hydrochloride; Akt inhibitor GSK2141795; GDC-0068 (related analog); Protein Kinase B Inhibitor GSK2141795
EINECS	Contact for details

Quality Control

Our Gsk2141795 (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for research use. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), identity confirmation (by NMR and MS), and impurity profiles is provided with every shipment to guarantee reliable and reproducible research results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.