Description

Gsk2141795 CAS NO 1047634-65-0 is a potent and selective small molecule inhibitor of the AKT (Protein Kinase B) signaling pathway. This compound is a critical research tool for investigating cellular processes related to cell survival, proliferation, and metabolism. It is primarily utilized by pharmaceutical researchers and life science companies engaged in oncology, metabolic disease, and signal transduction research. The high specificity of this inhibitor makes it invaluable for target validation and preclinical studies.

Application

• Biochemical Research: Used as a selective AKT inhibitor to study the PI3K/AKT/mTOR signaling pathway in vitro.
• Oncology Research: Investigated for its potential to inhibit tumor cell growth and proliferation in cancer models.
• Cell Signaling Studies: Essential for elucidating the role of AKT in cellular survival, apoptosis, and glucose metabolism.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for developing novel therapeutics targeting AKT.
• Academic Research: Employed in university and institutional labs for fundamental research into kinase biology and disease mechanisms.

Basic Information

Product Name	Gsk2141795
CAS No.	1047634-65-0
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	Uprosertib; GSK2141795; GSK-2141795; 5-[2,6-Di-4-morpholinyl-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; AZD-5363 analog; Akt inhibitor GSK2141795
EINECS	Contact for details

Quality Control

Our Gsk2141795 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.