Description

7-Deaza-2'-C-Ethynyladenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and oligonucleotide synthesis. Its unique 7-deaza and 2'-C-ethynyl modifications confer enhanced stability and binding affinity, making it a critical intermediate for developing novel therapeutics. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, antisense oligonucleotide (ASO) development, and the synthesis of modified RNA/DNA probes.

Application

• Antiviral Drug Discovery: Serves as a crucial scaffold for the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents targeting RNA viruses.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified bases into ASOs to enhance target binding affinity, nuclease resistance, and pharmacokinetic properties.
• siRNA and miRNA Research: Employed in the chemical synthesis of modified small interfering RNA (siRNA) and microRNA (miRNA) strands to improve stability and efficacy in gene silencing applications.
• Medicinal Chemistry & SAR Studies: Acts as a versatile intermediate for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based drug candidates.
• Diagnostic Probe Development: Utilized in creating labeled nucleotide probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic techniques.
• Biochemical Research: Applied in enzymatic studies to investigate polymerase fidelity, substrate specificity, and inhibition mechanisms.

Basic Information

Product Name	7-Deaza-2'-C-Ethynyladenosine
CAS No.	1044589-82-3
Molecular Formula	C₁₃H₁₄N₄O₄
Molecular Weight	290.27 g/mol
Synonyms	7-Deaza-2'-C-ethynyladenosine; 2'-C-ethynyl-7-deazaadenosine; 7-Deaza-2'-ethynyladenosine; 4-Amino-7-[(2R,3R,4S,5R)-3-ethynyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrrolo[2,3-d]pyrimidine; 7-Deaza-2'-C-ethynyl-A; Modified Adenosine Nucleoside; 7-Deaza-E-Ado
EINECS	Contact for details

Quality Control

Our 7-Deaza-2'-C-Ethynyladenosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.