Description

3-Cyanovinyl-9-(5'-o-(4,4'-Dimethoxytrityl)-2'-Deoxyribofuranosyl)Carbazole is a sophisticated, high-purity nucleoside phosphoramidite derivative, a critical building block in automated oligonucleotide synthesis. This compound is engineered to ensure high coupling efficiency and yield, which is paramount for the production of research-grade and therapeutic nucleic acids. It is an essential raw material for biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNAs, aptamers, and diagnostic probes.

Application

• Solid-Phase Oligonucleotide Synthesis: As a phosphoramidite monomer for the precise, stepwise assembly of custom DNA and RNA sequences on automated synthesizers.
• Therapeutic Nucleic Acid Development: A key reagent in the production of antisense drugs, small interfering RNA (siRNA), and other oligonucleotide-based therapeutics.
• Research Probe Synthesis: Used to manufacture labeled or modified oligonucleotides for use as hybridization probes, primers, and molecular beacons in genetic research and diagnostics.
• Aptamer and SELEX Technology: Enables the synthesis of complex, modified oligonucleotide libraries for the selection of high-affinity binding molecules.
• Diagnostic Assay Manufacturing: Critical for producing the specific capture and detection sequences used in PCR kits, microarrays, and other molecular diagnostic platforms.

Basic Information

Product Name	3-Cyanovinyl-9-(5'-o-(4,4'-Dimethoxytrityl)-2'-Deoxyribofuranosyl)Carbazole
CAS No.	1044273-26-8
Molecular Formula	C41H37N3O5
Molecular Weight	651.76 g/mol
Synonyms	9-(5-O-(4,4'-Dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-3-vinylcarbazole-1-carbonitrile; 3-Cyanovinyl Carbazole DMT Deoxyribonucleoside Phosphoramidite precursor; DMT-Carbazole(Cy-vinyl)-Deoxyriboside; 1-Cyanoethenyl-9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-ribofuranosyl]-9H-carbazole; Carbazole-modified deoxyribonucleoside; Oligonucleotide synthesis monomer CEV-dC
EINECS	Contact for details

Quality Control

Every batch of 3-Cyanovinyl-9-(5'-o-(4,4'-Dimethoxytrityl)-2'-Deoxyribofuranosyl)Carbazole is manufactured and tested under strict quality management systems. We ensure compliance with the high-purity standards required for sensitive oligonucleotide synthesis applications. Comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry, is documented in a detailed Certificate of Analysis (COA), which is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opened for use to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.