Description

Pf-00299804 is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is critical for advanced pharmaceutical research and development, particularly in the field of targeted cancer therapies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel kinase inhibitors. The product is supplied under stringent quality control to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced kinase inhibitor candidates for oncology research.
• Biochemical Research: Used as a reference standard or active agent in enzymatic and cellular assays to study specific biological pathways.
• Preclinical Development: Serves as a critical material for formulation studies, pharmacokinetic (PK) and pharmacodynamic (PD) profiling in drug discovery pipelines.
• Chemical Synthesis: Employed in organic synthesis for the preparation of more complex molecular entities with targeted therapeutic activity.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and signal transduction.

Basic Information

Product Name	Pf-00299804
CAS No.	1042385-75-0
Molecular Formula	C24H25ClFN5O2
Molecular Weight	477.94 g/mol
Synonyms	PF-00299804; PF 00299804; 1042385-75-0; Dacomitinib Intermediate; (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydro-3-furanyl]oxy}-6- quinazolinyl}-4-(dimethylamino)-2-butenamide; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; Dacomitinib (PF-00299804); PF00299804
EINECS	Contact for details

Quality Control

Our Pf-00299804 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to confirm identity and purity, ensuring it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.