Description

4-o-Acetyl-2,5-Anhydro-1,3-o-Isopropylidene-6-[Bis(2-Cyanoethyl)Phosphoryl]-D-Glucitol is a sophisticated, high-purity chemical intermediate featuring a protected sugar scaffold modified with a phosphonate ester group. This compound matters for its role as a key building block in the synthesis of complex nucleoside analogs and other biologically active molecules, enabling precise structural modifications. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing antiviral agents, nucleotide therapeutics, and advanced diagnostic probes.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer research.
• Antiviral Drug Development: Serves as a key scaffold for modifying sugar-phosphate backbones in potential therapeutic agents targeting viral polymerases.
• Pro-drug Synthesis: Used to create masked or protected forms of active pharmaceutical ingredients (APIs) to improve bioavailability and stability.
• Bioconjugation & Labeling: The reactive phosphonate ester and protected hydroxyl groups allow for site-specific conjugation with biomarkers or other molecules.
• Chemical Biology Research: Employed in the study of carbohydrate metabolism and enzyme inhibition mechanisms.
• Fine Chemical Manufacturing: A specialized intermediate for custom synthesis and contract manufacturing of complex organic molecules.

Basic Information

Product Name	4-o-Acetyl-2,5-Anhydro-1,3-o-Isopropylidene-6-[Bis(2-Cyanoethyl)Phosphoryl]-D-Glucitol
CAS No.	1041021-85-5
Molecular Formula	C19H27N2O8P
Molecular Weight	442.41 g/mol
Synonyms	1,3-O-Isopropylidene-4-O-acetyl-2,5-anhydro-6-O-[bis(2-cyanoethoxy)phosphinyl]-D-glucitol; 2,5-Anhydro-1,3-O-isopropylidene-4-O-acetyl-6-O-[bis(2-cyanoethyl)phosphoryl]-D-glucitol; 6-O-[Bis(2-cyanoethyl)phosphoryl]-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose derivative; D-Glucitol, 4-O-acetyl-2,5-anhydro-1,3-O-(1-methylethylidene)-6-[bis(2-cyanoethoxy)phosphinyl]-; Phosphorocyanatoethyl D-Glucitol Derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality control protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.