Description

1-(5-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-Ol is a high-value fluorinated aromatic building block, a key intermediate in modern synthetic chemistry. Its core value lies in providing a trifluoromethylated alcohol moiety attached to a halogenated aromatic ring, enabling precise structural modifications for advanced material and pharmaceutical development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require sophisticated intermediates for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine and bromine substituents enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a key starting material for synthesizing fluorinated components used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Advanced Polymer Modification: Employed to introduce fluorine-containing functional groups into polymer chains, improving material properties like chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck), allowing for the construction of complex biaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-(5-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-Ol
CAS No.	1039827-16-1
Molecular Formula	C8H5BrF4O
Molecular Weight	273.02 g/mol
Synonyms	5-Bromo-2-fluoro-α-(trifluoromethyl)benzyl alcohol; (5-Bromo-2-fluorophenyl)(trifluoromethyl)methanol; 1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethanol; α-(Trifluoromethyl)-5-bromo-2-fluorobenzyl alcohol; 2-Fluoro-5-bromo-α-(trifluoromethyl)benzyl alcohol; 1039827-16-1; 5-Bromo-2-fluoro-α-(trifluoromethyl)benzyl alcohol
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-2-Fluorophenyl)-2,2,2-Trifluoroethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements of advanced synthetic applications. Certificates of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR, NMR), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.