Description

R428 CAS NO 1037624-75-1 is a potent and selective small molecule inhibitor primarily targeting specific kinase pathways involved in cellular signaling. This compound is valued for its high purity and consistent performance in demanding research and development environments. It is essential for pharmaceutical researchers, medicinal chemists, and biologists working in oncology, immunology, and other life science fields requiring precise biochemical modulation.

Application

• Biochemical Research: Used as a selective kinase inhibitor in enzymatic assays and signal transduction pathway studies.
• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutic agents.
• Cell Biology Studies: Employed to investigate the role of specific kinases in cell proliferation, differentiation, and apoptosis in vitro.
• Preclinical Development: Utilized in animal model studies to evaluate the efficacy and pharmacokinetics of potential drug candidates.
• High-Throughput Screening (HTS): Acts as a control compound in screening libraries to identify new drug leads.

Basic Information

Product Name	R428
CAS No.	1037624-75-1
Molecular Formula	C28H34N8O2
Molecular Weight	514.62 g/mol
Synonyms	BGB324; BGB-324; Bemcentinib; 6-[2,6-Dichloro-4-[[3-(dimethylamino)propyl]carbamoyl]phenoxy]-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-carboxamide; R-428; UNII-0K2K4420VW; Axl Kinase Inhibitor R428; 5-Pyridinecarboxamide, 6-[2,6-dichloro-4-[[[3-(dimethylamino)propyl]amino]carbonyl]phenoxy]-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-
EINECS	Contact for details

Quality Control

Our R428 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.