Description

Cyclobutanecarbonyl Chloride, 1-(Trifluoromethyl)- is a high-value, specialized organofluorine building block used in advanced chemical synthesis. This compound matters for its unique structural features, combining a reactive acid chloride group with a cyclobutane ring and a trifluoromethyl substituent, enabling the introduction of a specific fluorinated moiety into target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for specialty monomers or polymers with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the creation of novel fluorinated ligands for catalysis and molecular recognition applications.
• PET (Positron Emission Tomography) Tracer Precursor: Potential use in the synthesis of fluorinated radiotracers for diagnostic imaging.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Item	Details
Product Name	Cyclobutanecarbonyl Chloride, 1-(Trifluoromethyl)-
CAS No.	1033538-21-4
Molecular Formula	C6H6ClF3O
Molecular Weight	186.56 g/mol
Synonyms	1-(Trifluoromethyl)cyclobutanecarbonyl chloride; 1-(Trifluoromethyl)cyclobutanecarboxylic acid chloride; 1-Trifluoromethylcyclobutane-1-carbonyl chloride; Cyclobutanecarboxylic acid, 1-(trifluoromethyl)-, chloride; 1-(Trifluoromethyl)cyclobutylcarbonyl chloride; (1-(Trifluoromethyl)cyclobutyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonyl Chloride, 1-(Trifluoromethyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and allowed to reach room temperature before opening to prevent moisture ingress. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.