Description

Ceritinib (LDK378) is a potent and selective small-molecule inhibitor of anaplastic lymphoma kinase (ALK), a key therapeutic target in oncology. This compound is critical for the research and development of targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC) with ALK rearrangements. It is an essential raw material for pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of active pharmaceutical ingredients (APIs) and reference standards.

Application

• Primary active pharmaceutical ingredient (API) in the manufacture of targeted oncology drugs.
• Critical reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research and preclinical studies for ALK-positive cancers.
• Biochemical tool for investigating ALK signaling pathways and mechanisms of drug resistance in academic and institutional research.
• Starting material for the synthesis of novel drug derivatives and prodrugs in medicinal chemistry programs.
• Component in the formulation of in-vitro diagnostic assays and research kits.

Basic Information

Product Name	Ceritinib (LDK378)
CAS No.	1032900-25-6
Molecular Formula	C28H36ClN5O3S
Molecular Weight	558.14 g/mol
Synonyms	LDK378; LDK-378; Zykadia™; 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine; Certinib; 1032900-25-6
EINECS	Contact for details

Quality Control

Our Ceritinib is manufactured under strict quality management systems to ensure the highest standards of purity and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, impurity profile, and identification. We adhere to cGMP guidelines where applicable, and our quality control protocols are designed to meet the rigorous demands of pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.