Description

(S)-1-[4-[[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)Thieno[3,2-D]Pyrimidin-6-Yl]Methyl]Piperazin-1-Yl]-2-Hydroxypropan-1-One is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound is valued for its role as a key building block in the synthesis of targeted kinase inhibitors, offering researchers a critical starting material with defined stereochemistry. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutics for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel, small-molecule kinase inhibitors targeting specific cancer pathways.
• Preclinical Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key precursor in the multi-step synthesis of potential drug candidates under Good Manufacturing Practice (GMP) conditions.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening and enzymatic assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical innovation pipelines.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and signal transduction.

Basic Information

Item	Detail
Product Name	(S)-1-[4-[[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)Thieno[3,2-D]Pyrimidin-6-Yl]Methyl]Piperazin-1-Yl]-2-Hydroxypropan-1-One
CAS No.	1032754-93-0
Molecular Formula	C24H31N9O3S
Molecular Weight	525.63 g/mol
Synonyms	(S)-1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one; (S)-PF-06447475; PF-06447475 (S-enantiomer); (S)-Enantiomer of PF-06447475; LRRK2 Kinase Inhibitor Intermediate; (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
EINECS	Contact for details

Quality Control

Our production of (S)-1-[4-[[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)Thieno[3,2-D]Pyrimidin-6-Yl]Methyl]Piperazin-1-Yl]-2-Hydroxypropan-1-One adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.