Description

Bay 80-6946 (Copanlisib) is a potent and selective phosphatidylinositol 3-kinase (PI3K) inhibitor, specifically targeting the p110α and p110δ isoforms. This compound is of significant value in oncology research and pharmaceutical development for its role in targeting aberrant PI3K signaling pathways. It is primarily needed by pharmaceutical companies, biotechnology research institutions, and academic laboratories engaged in the discovery and development of novel cancer therapeutics.

Application

• Pharmaceutical Intermediate: A key active pharmaceutical ingredient (API) in the formulation of targeted cancer therapies.
• Oncology Research: Used as a critical reference standard and tool compound in preclinical studies to investigate PI3K pathway biology and tumorigenesis.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and in vitro assays to identify and validate new drug candidates targeting PI3K.
• Mechanism of Action Studies: Utilized to study cell proliferation, apoptosis, and angiogenesis in various cancer cell lines and animal models.
• Clinical Trial Material: Sourced for the manufacturing of drug products used in clinical trials for hematologic malignancies and solid tumors.
• Academic Research: Serves as a vital reagent for university and institutional research into signal transduction and targeted therapy resistance mechanisms.

Basic Information

Product Name	Bay 80-6946 (Copanlisib)
CAS No.	1032568-63-0
Molecular Formula	C23H28FN9O3
Molecular Weight	497.53 g/mol
Synonyms	Copanlisib; BAY 80-6946; BAY-80-6946; Aliqopa (brand name); 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; PI3K Inhibitor BAY 80-6946; (S)-2-Amino-N-(7-methoxy-8-((3-morpholinopropoxy)quinazolin-5-yl)pyrimidine-5-carboxamide
EINECS	Contact for details

Quality Control

Our Bay 80-6946 (Copanlisib) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as HPLC purity, water content, and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. For short-term use, the material may be stored at 2-8°C. The product is hygroscopic and should be handled in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.