Description

Mk-2206 CAS NO 1032349-93-1 is a potent and selective allosteric inhibitor of the Akt (Protein Kinase B) signaling pathway. This compound is a critical research tool for investigating cellular processes related to proliferation, survival, and metabolism, with significant implications for oncology and metabolic disease research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in preclinical drug discovery and target validation studies.

Application

• Biomedical Research: A key pharmacological probe for studying the role of Akt isoforms (Akt1, Akt2, Akt3) in various cellular signaling pathways.
• Oncology Research: Used in in vitro and in vivo studies to investigate tumor growth inhibition, apoptosis induction, and chemosensitization in cancer cell lines.
• Metabolic Disease Studies: Applied in research exploring insulin signaling, glucose homeostasis, and the pathophysiology of diabetes.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and synthesis of novel Akt inhibitors.
• Signal Transduction Analysis: Essential for elucidating the PI3K/Akt/mTOR pathway and its crosstalk with other oncogenic pathways.

Basic Information

Product Name	Mk-2206
CAS No.	1032349-93-1
Molecular Formula	C28H41N7O3
Molecular Weight	523.67 g/mol
Synonyms	8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; Akt Inhibitor VIII; Akti-1/2; 1,2,4-Triazolo[3,4-f][1,6]naphthyridine, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2,3-dihydro-3-oxo-
EINECS	Contact for details

Quality Control

Our Mk-2206 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.