Description

1-[(4R,5R)-4,5-Dihydroxy-L-Ornithine]Echinocandin B Hydrochloride (1:1) is a high-purity, semi-synthetic derivative of the potent antifungal lipopeptide, Echinocandin B. This compound serves as a critical advanced intermediate in the pharmaceutical synthesis of next-generation antifungal agents, offering a strategic starting point for targeted chemical modifications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel antifungal therapeutics targeting invasive fungal infections.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel echinocandin-class antifungal drugs, such as caspofungin and micafungin analogs.
• Antifungal Research: Used as a reference standard and active compound in biochemical and microbiological research to study the mechanism of action of glucan synthase inhibitors.
• Process Development: Employed in the scale-up and optimization of fermentation and semi-synthetic routes for complex lipopeptide antibiotics.
• Quality Control: Serves as a high-purity analytical standard for the identification and quantification of echinocandin derivatives in drug substances and finished products.

Basic Information

Item	Details
Product Name	1-[(4R,5R)-4,5-Dihydroxy-L-Ornithine]Echinocandin B Hydrochloride (1:1)
CAS No.	1029890-89-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Echinocandin B Ornithine Derivative Hydrochloride; (4R,5R)-4,5-Dihydroxy-L-ornithine-Echinocandin B HCl; Echinocandin B Derivative; L-Ornithine, N5-[4-[[4-[(4R,5R)-4,5-dihydroxy-N2-[(4R,5R)-5-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-4-hydroxy-2-(1H-indol-3-ylmethyl)-5-oxo-1,3-oxazolidin-4-yl]-L-ornithyl]phenyl]methyl]-1-piperazinyl]-N2-[(4R,5R)-5-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-4-hydroxy-2-(1H-indol-3-ylmethyl)-5-oxo-1,3-oxazolidin-4-yl]-, hydrochloride (1:1); A40926 Derivative Hydrochloride; Pneumocandin B0 Ornithine Amide Hydrochloride
EINECS	Contact for details

Quality Control

Our 1-[(4R,5R)-4,5-Dihydroxy-L-Ornithine]Echinocandin B Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Bacterial Endotoxins	<1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.