Description

Capmatinib is a highly selective and potent small-molecule inhibitor of the mesenchymal-epithelial transition (MET) receptor tyrosine kinase. This targeted therapeutic agent is crucial for advanced pharmaceutical research and development, particularly in precision oncology. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the discovery and development of novel cancer treatments, especially for non-small cell lung cancer (NSCLC) and other MET-dysregulated tumors.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active pharmaceutical ingredient in the formulation of targeted cancer therapies.
• Oncology Research: A critical reference standard and tool compound for in vitro and in vivo studies investigating MET signaling pathways and tumor biology.
• Preclinical Development: Used in pharmacokinetics (PK), pharmacodynamics (PD), and toxicology studies to support Investigational New Drug (IND) applications.
• Biomarker Development: Employed in companion diagnostic research to identify patient populations with MET exon 14 skipping mutations or MET amplification.
• Combination Therapy Studies: Investigated in research settings for potential synergistic effects when combined with other anticancer agents, such as EGFR inhibitors.
• Chemical Intermediate: Used in the synthesis of more complex molecules or deuterated analogs for advanced research purposes.

Basic Information

Item	Details
Product Name	Capmatinib
CAS No.	1029712-80-8
Molecular Formula	C23H17FN6O
Molecular Weight	412.42 g/mol
Synonyms	INC280; INCB-028060; N-[4-(7-Azaindol-3-yl)phenyl]-4-[(3,5-dimethyl-4-oxo-1,4-dihydropyrazolo[3,4-d]pyrimidin-6-yl)amino]-2-fluorobenzamide; 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide; Capmatinib Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Capmatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR, MS), and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) that detail all test results, ensuring compliance with the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.