Description

Plx3397 (Pexidartinib) is a potent and selective small molecule inhibitor of the colony-stimulating factor 1 receptor (CSF1R). This compound is of significant interest for its targeted mechanism of action, which modulates tumor-associated macrophages and the tumor microenvironment. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology drug discovery and preclinical development for applications in solid tumors and tenosynovial giant cell tumors.

Application

• Oncology Research & Drug Discovery: A key tool compound for investigating the role of CSF1R signaling in tumor progression and metastasis.
• Preclinical Development: Used in in vitro and in vivo studies to validate CSF1R as a therapeutic target and assess compound efficacy.
• Immuno-oncology Studies: Facilitates research into the tumor microenvironment, specifically the modulation of macrophage polarization and function.
• Biomarker Research: Supports studies aimed at identifying patient populations that may respond to CSF1R-targeted therapies.
• Chemical Probe: Serves as a selective probe in biochemical and cellular assays to understand CSF1R kinase biology.
• Reference Standard: Used as an analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	Plx3397 (Pexidartinib)
CAS No.	1029044-16-3
Molecular Formula	C₂₀H₁₅F₃N₆O
Molecular Weight	412.37 g/mol
Synonyms	Pexidartinib; PLX-3397; PLX3397; 5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine; TURALIO (brand name); CSF1R Inhibitor PLX3397; UNII-8N5FD6F6QO
EINECS	Contact for details

Quality Control

Our Plx3397 (Pexidartinib) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality guidelines suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.