Description

3-(tert-Butyldimethylsilanyloxy)Cyclohexanol is a protected cyclohexanol derivative, specifically a tert-butyldimethylsilyl (TBDMS) ether, serving as a crucial chiral intermediate in advanced organic synthesis. Its primary value lies in providing a robust, sterically hindered protecting group for the hydroxyl function, enabling selective reactions elsewhere on the molecule under a wide range of conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the multi-step synthesis of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral drug candidates, especially those requiring stereoselective hydroxyl group protection.
• Asymmetric Synthesis: Used as a chiral auxiliary or starting material in catalytic asymmetric reactions to construct complex molecular architectures.
• Fine Chemical Production: Intermediate for manufacturing high-value specialty chemicals, flavors, and fragrances where precise stereochemistry is critical.
• Agrochemical Research: Serves as a precursor in developing novel, stereochemically defined pesticides and herbicides.
• Academic & R&D Laboratories: Valuable reagent for methodological development in organic chemistry and total synthesis projects.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with tailored properties.

Basic Information

Product Name	3-(tert-Butyldimethylsilanyloxy)Cyclohexanol
CAS No.	1028748-71-1
Molecular Formula	C₁₂H₂₆O₂Si
Molecular Weight	230.42 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]cyclohexanol; 3-(TBDMSO)-Cyclohexanol; Cyclohexanol, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 3-(tert-Butyldimethylsilyloxy)cyclohexan-1-ol; 3-(Tert-butyldimethylsiloxy)cyclohexanol; 3-Hydroxycyclohexyl tert-butyldimethylsilyl ether; TBDMS ether of 3-cyclohexanol
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsilanyloxy)Cyclohexanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.