Description

3-Pyrrolidinecarbonyl Chloride is a versatile and highly reactive acyl chloride derivative of the pyrrolidine heterocycle. This compound serves as a critical building block in modern synthetic chemistry, enabling the efficient introduction of the pyrrolidinecarbonyl moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system (CNS) and as protease inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the pyrrolidine scaffold imparts specific biological activity.
• Peptide Mimetics & PROTACs: Facilitates the construction of peptide-like structures and proteolysis-targeting chimeras (PROTACs) for drug discovery programs.
• Material Science: Acts as a monomer or coupling agent in the synthesis of specialized polymers and functional materials.
• Chemical Biology Probes: Employed to create molecular probes for studying enzyme function and biological pathways.
• Scale-Up Process Chemistry: Suitable for use in kilogram-scale laboratory and pilot plant syntheses due to its defined reactivity profile.

Basic Information

Product Name	3-Pyrrolidinecarbonyl Chloride
CAS No.	1025458-52-9
Molecular Formula	C5H8ClNO
Molecular Weight	133.57 g/mol
Synonyms	Pyrrolidine-3-carbonyl chloride; 3-Carbamoylpyrrolidine hydrochloride (precursor related); 3-Pyrrolidinecarboxylic acid chloride; 3-(Chlorocarbonyl)pyrrolidine; Pyrrolidin-3-ylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Pyrrolidinecarbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory requirements in advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.