Description

n-[3-tert-Butyl-1-(Quinolin-6-Yl)-1H-Pyrazol-5-Yl]-N'-[2-Fluoro-4-[(2-(Methylcarbamoyl)Pyridin-4-Yl)Oxy]Phenyl]Urea is a high-purity, non-peptidic small molecule compound designed for advanced research and development. This compound is a critical pharmacological research tool and a key intermediate in the synthesis of targeted therapeutics. It is primarily needed by pharmaceutical R&D laboratories and biotech companies engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for kinase-targeted therapies.
• Biochemical Research: Used as a reference standard or active compound in high-throughput screening (HTS) assays to identify and validate new biological targets.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Preclinical Development: Employed in the formulation and testing of prototype compounds for in vitro and in vivo efficacy and safety studies.
• Chemical Biology Probes: Can be utilized to study specific protein functions and signaling pathways within cellular systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	n-[3-tert-Butyl-1-(Quinolin-6-Yl)-1H-Pyrazol-5-Yl]-N'-[2-Fluoro-4-[(2-(Methylcarbamoyl)Pyridin-4-Yl)Oxy]Phenyl]Urea
CAS No.	1020226-00-9
Molecular Formula	C31H30FN7O4
Molecular Weight	583.62 g/mol
Synonyms	N-(3-(tert-Butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-N'-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea; 1-(3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea; BIRB 796; Doramapimod; MAPK Inhibitor; p38 MAP Kinase Inhibitor; BIRB-796; BIRB 0796
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all critical quality attributes. We support development under cGMP guidelines for applications requiring regulatory submission.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.