Description

5-Fluoro-4-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it provides a protected pyrrolopyridine scaffold with orthogonal halogen handles, enabling precise, sequential cross-coupling reactions critical for constructing complex molecular architectures. Pharmaceutical and agrochemical researchers need it for the efficient synthesis of novel active ingredients, particularly in medicinal chemistry for drug discovery programs targeting kinase inhibition and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Material Science: Serves as a specialized building block for creating organic electronic materials and functional dyes.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Cross-Coupling Reactions: The iodine and fluorine substituents make it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Directed Functionalization: The triisopropylsilyl (TIPS) protecting group allows for selective deprotection and further modification of the pyrrole nitrogen.

Basic Information

Product Name	5-Fluoro-4-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1020056-67-0
Molecular Formula	C17H24FIN2Si
Molecular Weight	430.38 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-4-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Fluoro-4-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-pyrrolo[2,3-b]pyridine; 1-(tert-Butyldimethylsilyl)-5-fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-4-iodo-1-((tert-butyldimethylsilyl))-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 5-Fluoro-4-Iodopyrrolopyridine; 4-Iodo-5-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged manipulations to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.