Description

3-Ethoxy-2,4-Difluorobenzoyl Chloride, 97% is a high-purity, functionalized benzoyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of an ethoxy group and fluorine atoms, which allows for precise modulation of electronic and steric properties in target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex intermediates for active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorinated benzoyl moiety.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, improving charge transport and thermal properties.
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer chains, altering surface properties, chemical resistance, and optical characteristics.
• Cross-Coupling Reactions: The acid chloride group is highly reactive in palladium-catalyzed cross-coupling and other metal-mediated transformations to form carbon-carbon bonds.
• Peptide & Protein Research: Can be used as an acylating agent for modifying amino acids or introducing fluorinated aromatic labels into biomolecules.

Basic Information

Product Name	3-Ethoxy-2,4-Difluorobenzoyl Chloride, 97%
CAS No.	1017779-90-6
Molecular Formula	C9H7ClF2O2
Molecular Weight	220.60 g/mol
Synonyms	2,4-Difluoro-3-ethoxybenzoyl chloride; 3-Ethoxy-2,4-difluorobenzoic acid chloride; Benzoic acid, 3-ethoxy-2,4-difluoro-, chloride; 1017779-90-6; 3-Ethoxy-2,4-difluorobenzoylchloride; 2,4-Difluoro-3-ethoxybenzoic acid chloride
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-2,4-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure it meets the specified 97% minimum purity and impurity profile. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and strong bases. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.