Description

3-(4-Fluorophenyl)-2-Methylpropanoyl Chloride is a high-purity fluorinated acid chloride building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel material science applications.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the fluorophenyl moiety for enhanced biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals, where the fluorine atom imparts unique electronic and surface properties.
• Peptide Mimetics & Conjugation: Employed in the acylation of amines and alcohols to create peptide-like structures or for bioconjugation strategies in probe development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production of client-specific molecules.

Basic Information

Product Name	3-(4-Fluorophenyl)-2-Methylpropanoyl Chloride
CAS No.	1017183-70-8
Molecular Formula	C10H10ClFO
Molecular Weight	200.64 g/mol
Synonyms	2-Methyl-3-(4-fluorophenyl)propanoyl chloride; 4-Fluoro-α-methylhydrocinnamoyl chloride; 3-(p-Fluorophenyl)-2-methylpropionyl chloride; 2-Methyl-3-(4-fluorophenyl)propionic acid chloride; (4-Fluorophenyl)-2-methylpropanoic acid chloride; p-Fluoro-α-methylhydrocinnamic acid chloride; 1017183-70-8
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)-2-Methylpropanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and REACH standards for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.