Description

Gefapixant CAS NO 1015787-98-0 is a potent and selective P2X3 receptor antagonist. This compound is of significant interest for its therapeutic potential in modulating chronic cough pathways. It is primarily utilized by pharmaceutical research and development organizations engaged in the discovery and production of novel treatments for respiratory conditions, particularly refractory or unexplained chronic cough.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) in the formulation of finished drug products.
• Chronic Cough Research: Used in preclinical and clinical research for developing treatments for refractory or unexplained chronic cough (RCC/UCC).
• P2X Receptor Studies: A critical reference standard in pharmacological studies targeting purinergic signaling, specifically the P2X3 receptor subtype.
• Drug Discovery: Employed as a lead compound or benchmark in medicinal chemistry programs focused on neurology and respiratory therapeutics.
• Analytical Standard: Used as a high-purity reference standard in quality control (QC) and analytical method development (e.g., HPLC, LC-MS).
• Formulation Development: Supports R&D in creating stable and bioavailable dosage forms, such as tablets or capsules.

Basic Information

Product Name	Gefapixant
CAS No.	1015787-98-0
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	MK-7264; AF-219; Gefapixant citrate; (5-({[(2,4-Dichlorophenyl)methyl]thio})-4-methyl-1,2,4-triazol-3-yl)(4-ethoxyphenyl)methanone; RO4925474; Compound 219; P2X3 antagonist MK-7264
EINECS	Contact for details

Quality Control

Our Gefapixant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.