Description

3',5'-Bis-o-Benzoyl-2'-Deoxy-2'-Fluoro--D-Arabino-6-Azidouridine is a sophisticated, high-purity nucleoside analog derivative, specifically engineered for advanced pharmaceutical research and development. This compound is a critical building block in the synthesis of modified oligonucleotides, offering researchers a precise tool for probing biological mechanisms and developing novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in antiviral drug discovery, antisense oligonucleotide (ASO) synthesis, and nucleic acid chemistry.

Application

• Antiviral Drug Development: Serves as a key intermediate in the synthesis of nucleoside analogs targeting viral polymerases.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified bases into oligonucleotides to enhance stability, binding affinity, and nuclease resistance.
• siRNA and miRNA Research: Acts as a building block for chemically modified RNA strands to improve pharmacokinetic properties.
• Probe and Diagnostic Development: The azido group allows for bioorthogonal "click chemistry" conjugation, useful for labeling and tracking nucleic acids.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship studies by introducing specific fluorine and azido modifications to the sugar moiety.
• Process Chemistry & Scale-up: Supplied in high purity for use in pilot-scale and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	3',5'-Bis-o-Benzoyl-2'-Deoxy-2'-Fluoro--D-Arabino-6-Azidouridine
CAS No.	1013470-68-2
Molecular Formula	C24H19FN4O8
Molecular Weight	510.43 g/mol
Synonyms	2'-Deoxy-2'-fluoro-6-azido-3',5'-di-O-benzoyl-arabinouridine; 6-Azido-2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyluracil; 2'-F-6-N3-araU(Bz)2; 2'-Fluoro-6-azido-3',5'-di-O-benzoyl-β-D-arabinouridine; 6-Azido-3',5'-di-O-benzoyl-2'-deoxy-2'-fluorouridine; 2'-F-ara-6-N3-U(Bz)2; 1013470-68-2
EINECS	Contact for details

Quality Control

Our production of 3',5'-Bis-o-Benzoyl-2'-Deoxy-2'-Fluoro--D-Arabino-6-Azidouridine adheres to stringent quality protocols suitable for research and pharmaceutical applications. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality management system supports compliance with relevant guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.