Description

4-((3-Ethynyl-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Ol is a high-purity, advanced pharmaceutical intermediate featuring a quinazoline core structure. This compound is critical for research and development in targeted cancer therapies, particularly as a key building block for tyrosine kinase inhibitors. It is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel oncology drug candidates. The material's specific structure allows for precise molecular modifications in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potent tyrosine kinase inhibitors (TKIs) for cancer treatment.
• Oncology Drug Discovery: Used as a scaffold in medicinal chemistry for designing and optimizing new small-molecule therapeutics targeting specific cancer pathways.
• Biochemical Research: Employed in vitro studies to investigate structure-activity relationships (SAR) and enzyme inhibition mechanisms.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Preclinical Development: Utilized in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.

Basic Information

Product Name	4-((3-Ethynyl-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Ol
CAS No.	1012057-64-5
Molecular Formula	C18H12FN3O2
Molecular Weight	321.31 g/mol
Synonyms	4-[(3-Ethynyl-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol; 7-Methoxy-4-((3-ethynyl-4-fluorophenyl)amino)quinazolin-6-ol; 4-(3-Ethynyl-4-fluoroanilino)-7-methoxyquinazolin-6-ol; Afatinib Intermediate; BIBW 2992 Intermediate; Tovok Intermediate; Giotrif Intermediate; Gilotrif Intermediate
EINECS	Contact for details

Quality Control

Every batch of 4-((3-Ethynyl-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Ol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.