Description

2'-Deoxy-2'-Fluoro-β-D-Arabino-2-Thiouridine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and oligonucleotide synthesis. Its modified sugar-phosphate backbone is critical for enhancing the stability, binding affinity, and nuclease resistance of synthetic oligonucleotides. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced therapeutics, including antisense oligonucleotides and siRNA-based drugs.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense Drug Development: Used to create oligonucleotides with improved metabolic stability and target affinity for therapeutic applications.
• siRNA and miRNA Research: Incorporated into small interfering RNA (siRNA) and microRNA (miRNA) to modulate gene expression with enhanced efficacy.
• Diagnostic Probe Manufacturing: Serves as a modified base in the production of high-specificity molecular probes and primers.
• Medicinal Chemistry & API Intermediates: A crucial scaffold for synthesizing novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Employed in structural and mechanistic studies of nucleic acid interactions and enzyme function.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro-β-D-Arabino-2-Thiouridine
CAS No.	1006872-85-0
Molecular Formula	C9H11FN2O5S
Molecular Weight	278.26 g/mol
Synonyms	2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl-2-thiouridine; 2'-F-ara-2-thiouridine; 2'-Fluoro-2'-deoxy-β-D-arabino-2-thiouridine; 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one; 2-Thio-2'-deoxy-2'-fluoroarabinouridine; 2'-F-2-thio-AraU; 2'-Fluoro-2-thioarabinouridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-β-D-Arabino-2-Thiouridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to stringent in-house specifications aligned with industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥98.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.