Description

2'-Deoxy-2'-Fluoro-Arabinoisocytidine is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate and a potential active pharmaceutical ingredient (API) in the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of next-generation nucleotide-based drugs, particularly those targeting RNA viruses and specific oncology pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Antiviral Drug Research: Investigated for its potential activity against RNA viruses, including hepatitis C virus (HCV) and other emerging viral pathogens.
• Oncology Research: Used in the development of targeted cancer therapies that interfere with DNA/RNA synthesis in rapidly dividing cells.
• Biochemical Tool: Employed in enzymatic studies and as a probe to understand nucleic acid metabolism and polymerase mechanisms.
• Preclinical Development: Supplied for use in in vitro and in vivo studies to assess pharmacokinetics, efficacy, and toxicity profiles.
• Process Chemistry: Used by process R&D teams to develop and scale up efficient synthetic routes for GMP manufacturing.

Basic Information

Item	Details
Product Name	2'-Deoxy-2'-Fluoro-Arabinoisocytidine
CAS No.	1006872-82-7
Molecular Formula	C9H12FN3O4
Molecular Weight	245.21 g/mol
Synonyms	2'-F-ara-isoC; 2'-Fluoro-2'-deoxy-arabinosylisocytidine; 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one; 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; β-D-Arabinofuranosyl, 2-fluoro-2-deoxy-, 4-aminopyrimidin-2-one nucleoside; 2'-Fluoro-arabinoisocytidine
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxy-2'-Fluoro-Arabinoisocytidine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings with comprehensive documentation. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming compliance with customer specifications and relevant quality guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.